Stephan von Gunten Selected Research

Sialic Acid Binding Immunoglobulin-like Lectins

12/2021	Targeting sialylation to treat central nervous system diseases.
1/2019	Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment.
11/2018	Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells.
1/2018	A Cartography of Siglecs and Sialyltransferases in Gynecologic Malignancies: Is There a Road Towards a Sweet Future?
1/2018	Targeting sialic acid-Siglec interactions to reverse immune suppression in cancer.
4/2015	Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense.
4/2014	Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.
8/2011	Targeting siglecs--a novel pharmacological strategy for immuno- and glycotherapy.

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Stephan von Gunten Research Topics

Disease

15	Neoplasms (Cancer) 01/2021 - 06/2009
4	Autoimmune Diseases (Autoimmune Disease) 11/2020 - 12/2006
4	Sepsis (Septicemia) 11/2020 - 12/2014
4	Inflammation (Inflammations) 01/2020 - 01/2016
3	Rheumatoid Arthritis 11/2020 - 08/2005
2	Hypersensitivity (Allergy) 01/2022 - 01/2021
2	Melanoma (Melanoma, Malignant) 12/2020 - 01/2019
2	Septic Shock (Toxic Shock Syndrome) 10/2009 - 08/2005
1	Chronic Disease (Chronic Diseases) 12/2021
1	Alveolar echinococcosis 01/2021
1	Anaphylaxis (Anaphylactic Shock) 01/2021
1	Cleft Lip (Harelip) 01/2021
1	Immediate Hypersensitivity 01/2021
1	Osteoporosis 12/2020
1	Neoplasm Metastasis (Metastasis) 12/2020
1	Crohn Disease (Crohn's Disease) 11/2020
1	Relapsing-Remitting Multiple Sclerosis 01/2020
1	Primary Immunodeficiency Diseases 11/2019
1	Reinfection 11/2019
1	Atherosclerosis 01/2019
1	Hypoxia (Hypoxemia) 01/2019
1	Infertility (Sterility) 01/2019
1	Kidney Neoplasms (Kidney Cancer) 11/2018
1	Ovarian Neoplasms (Ovarian Cancer) 11/2018
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2018
1	Multiple Sclerosis 02/2016
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 02/2016
1	Neuroinflammatory Diseases 02/2016
1	Endotoxemia 01/2016
1	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 01/2013
1	Asthma (Bronchial Asthma) 01/2012
1	Pulmonary Hypertension 12/2011
1	Vascular Diseases (Vascular Disease) 12/2011
1	Systemic Scleroderma (Systemic Sclerosis) 12/2011
1	Stevens-Johnson Syndrome (Lyell's Syndrome) 05/2010
1	Shock 10/2009
1	Churg-Strauss Syndrome (Allergic Angiitis) 04/2007
1	Neutropenia 12/2006

Drug/Important Bio-Agent (IBA)

8	Sialic Acid Binding Immunoglobulin-like LectinsIBA 12/2021 - 08/2011
8	Intravenous Immunoglobulins (IVIG)FDA Link 11/2020 - 12/2006
6	Polysaccharides (Glycans)IBA 01/2022 - 06/2009
5	Immunoglobulin G (IgG)IBA 01/2021 - 02/2016
4	AntibodiesIBA 01/2021 - 12/2011
3	AntigensIBA 11/2019 - 06/2009
3	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/2019 - 01/2018
2	AutoantibodiesIBA 01/2021 - 04/2007
2	SialyltransferasesIBA 01/2021 - 01/2018
2	ArginaseIBA 12/2020 - 01/2020
2	Immunoglobulin A (IgA)IBA 11/2020 - 12/2014
2	CarbohydratesIBA 11/2019 - 12/2011
2	LigandsIBA 01/2019 - 04/2014
2	Proteins (Proteins, Gene)FDA Link 11/2018 - 01/2012
2	Blocking AntibodiesIBA 01/2018 - 05/2010
2	CytokinesIBA 01/2016 - 01/2012
2	LectinsIBA 04/2015 - 04/2014
1	anti-IgE antibodiesIBA 01/2021
1	SugarsIBA 01/2021
1	Immunoglobulin E (IgE)IBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	Interferon Regulatory FactorsIBA 01/2021
1	GlucocorticoidsIBA 12/2020
1	Superoxide DismutaseIBA 12/2020
1	PolyaminesIBA 12/2020
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2020
1	CatalaseIBA 12/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	Therapeutic UsesIBA 01/2020
1	Pharmaceutical PreparationsIBA 01/2019
1	Mixed Function Oxygenases (Monooxygenases)IBA 01/2019
1	GangliosidesIBA 01/2019
1	EnzymesIBA 01/2019
1	CytidineIBA 01/2019
1	AcidsIBA 01/2019
1	Carbonic Anhydrase IXIBA 11/2018
1	G250 monoclonal antibodyIBA 11/2018
1	Biological ProductsIBA 01/2018
1	Sialic AcidsIBA 01/2018
1	Complement System Proteins (Complement)IBA 01/2016
1	Galectins (Galectin)IBA 04/2015
1	SelectinsIBA 04/2015
1	C-Type Lectins (C-Type Lectin)IBA 04/2015
1	Carrier Proteins (Binding Protein)IBA 04/2014
1	Inosine Triphosphate (ITP)IBA 01/2013
1	Death Domain ReceptorsIBA 05/2010
1	fas Receptor (CD95 Antigen)IBA 08/2005
1	CaspasesIBA 08/2005

Therapy/Procedure

4	Immunotherapy 01/2019 - 08/2011
3	Therapeutics 04/2014 - 12/2006
1	Heterologous Transplantation (Xenotransplantation) 01/2019
1	Radiotherapy 01/2016
1	Transplantation 04/2015
1	Critical Care (Surgical Intensive Care) 10/2009
1	Ligation 10/2009